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Merkel cell carcinoma: an aggressive neoplasm
1United Hospital Center, Clarksburg, USA.
The West Virginia Medical Journal
|June 3, 1999
Summary
This case report details a rare Merkel cell carcinoma (MCC) of the skin, presenting as a thigh mass and inguinal lymph node involvement. Prompt diagnosis and treatment, including surgery and radiation, are crucial for this aggressive cancer.
Area of Science:
- Oncology
- Dermatopathology
- Surgical Oncology
Background:
- Merkel cell carcinoma (MCC), also known as trabecular carcinoma or cutaneous small cell undifferentiated carcinoma (CSCUC), is a rare and aggressive skin cancer.
- Early detection and prompt treatment are critical due to its unfavorable prognosis and high risk of metastasis.
Observation:
- A patient presented with a palpable, non-tender mass on the right upper thigh and a significantly enlarged right inguinal lymph node.
- Microscopic examination of the thigh lesion and inguinal lymph node biopsy confirmed the presence of Merkel cell carcinoma.
Findings:
- Immunoperoxidase stains were utilized to confirm the diagnosis of Merkel cell carcinoma in both the primary skin lesion and the metastatic lymph node.
- The findings highlight the potential for MCC to present initially as a thigh mass with regional lymph node involvement.
Implications:
- This case underscores the importance of considering rare skin malignancies in the differential diagnosis of unexplained masses and lymphadenopathy.
- The standard treatment of wide local excision with adequate margins followed by radiation therapy is recommended for optimal patient outcomes in MCC.