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Complex interactions between skeletal muscle ryanodine receptor and dihydropyridine receptor proteins
1Banting and Best Department of Medical Research, Charles H. Best Institute, University of Toronto, ON, Canada.
Abstract:
Evidence for functional interactions between the Ca2+ release channel in the skeletal muscle sarcoplasmic reticulum (the ryanodine receptor) and the L-type Ca2+ channel in the sarcolemma (the dihydropyridine receptor), leading to excitation-contraction coupling, is reviewed and experimental systems used to identify candidate sites of interaction are outlined.