Related Experiment Video
Updated: Aug 8, 2026

Application of Electrophysiology Measurement to Study the Activity of Electro-Neutral Transporters
Published on: February 3, 2018
[The sodium-iodide-symporter (NIS): function, regulation and clinical importance]
1Abteilung für Molekulare Innere Medizin, Universität Würzburg. J.KOEHRLE@MAIL.UNI-WUERZBURG.DE
Abstract:
Cloning, functional characterisation, and diagnostic proof of the expression of sodium-iodide-symporter (NIS) in the thyroid are essential steps for a better understanding of function and regulation of thyroid hormone synthesis, which is limited by the availability of the trace element iodide. The physiological or pharmacological modulation of NIS function can now be used for a rational functional diagnosis and therapy of thyroid diseases. Diagnostic procedures based on analysis of the this gene or its expression are already in use for the analysis of benign and malignant alterations of the thyroid. Experimental protocols aiming at the functional expression of NIS in thyroid tumors or their metastases which lost capability for iodide uptake are currently developed. Furthermore, techniques are under investigation to express functional NIS by gene transfer in those benign or malignant tissues, tumors, metastases, which normally do not accumulate iodide. This would allow application of radioiodide therapy, a save and established technique to non-thyroid-related fatal diseases.
More Related Videos
Related Concept Videos
Secondary Active Transport
The Significance of Membrane Transport
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Secondary Active Transport
Transcellular Transport of Solutes
Reabsorption and Secretion in the Loop of Henle
Active Transport
Primary active transporters, like Na+, K+ and -ATPase, directly utilize ATP to move ions across the membrane. These transporters play significant roles in various physiological processes. For instance, Na+, K+ and -ATPase maintain...

![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)