Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent innovations in total liquid ventilation system and component design.

K M Sekins1, L Nugent, M Mazzoni

  • 1Alliance Pharmaceutical Corp., San Diego, California, USA.

Biomedical Instrumentation & Technology
|June 9, 1999
PubMed
Summary

Total liquid ventilation (TLV) is a lung therapy using oxygenated perfluorochemical (PFC) liquid. Innovations in liquid ventilator components are crucial for scaling TLV to adult lungs, addressing challenges in gas exchange and system design.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Avelumab first-line maintenance for advanced urothelial carcinoma: long-term outcomes from the JAVELIN Bladder 100 trial in patients with high body mass index or diabetes mellitus.

ESMO open·2026
Same author

Search for Axion Dark Matter from 1.1 to 1.3 GHz with ADMX.

Physical review letters·2025
Same author

Systemic antibiotic use in fire-affected koalas (Phascolarctos cinereus) admitted to two wildlife treatment facilities during the 2019-2020 wildfires.

Australian veterinary journal·2025
Same author

Safety, Pharmacokinetics, and Acceptability of a Tenofovir Rectal Microbicide Douche Among Young Men Who Have Sex With Men: The DREAM ATN Study (ATN 163).

The Journal of infectious diseases·2025
Same author

ADMX Axion Dark Matter Bounds around 3.3  μeV with Dine-Fischler-Srednicki-Zhitnitsky Discovery Ability.

Physical review letters·2025
Same author

Avelumab first-line maintenance for advanced urothelial carcinoma: long-term outcomes from the JAVELIN Bladder 100 trial in older patients.

ESMO open·2025

Area of Science:

  • Biomedical Engineering
  • Respiratory Physiology
  • Critical Care Medicine

Background:

  • Partial liquid ventilation (PLV) and total liquid ventilation (TLV) are explored for lung injury and failure.
  • Current TLV research primarily targets small lungs (e.g., pediatric patients).
  • Scaling TLV to adult lungs presents significant engineering and physiological challenges.

Purpose of the Study:

  • To address the design challenges of liquid ventilators for adult total liquid ventilation.
  • To present innovations in TLV system components for large-animal applications.
  • To discuss the advantages of novel pumps, gas exchangers, and temperature control for adult TLV.

Main Methods:

  • Development of a new large-animal liquid ventilator prototype.

Related Experiment Videos

  • Implementation of innovative pumps, gas exchangers, and temperature-control components.
  • Focus on addressing practical problems in scaling TLV, including priming volume, PFC loss, cavitation, and pressure monitoring.

    • Main Results:

    • A new large-animal liquid ventilator prototype was developed with specific component innovations.
    • The study addresses key challenges in adult TLV, such as higher volume delivery and gas exchange.
    • Advantages of new pumps, gas exchangers, and temperature control for enhanced TLV performance are discussed.

    Conclusions:

    • Scaling total liquid ventilation to adult lungs requires significant advancements in liquid ventilator technology.
    • Innovations in pumps, heat exchangers, and control systems are essential for effective adult TLV.
    • The presented prototype and component advancements offer solutions for future clinical applications of TLV in adults.