Secondary hormonal manipulations in hormone refractory prostate cancer

Hormone refractory prostate cancer is clinically heterogeneous, and many patients retain sensitivity to subsequent hormonal manipulations, even after combined androgen blockage. Antiandrogen withdrawal is a mandatory first step. Subsequent treatment with an alternate antiandrogen, adrenal androgen inhibitor (such as ketoconazole), or glucocorticoid may provide both subjective and objective clinical benefit in up to 65% of patients.