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JaDis: computing distances between nucleic acid sequences.

I Gonçalves1, M Robinson, G Perrière

  • 1Laboratoire de Biométrie, Génétique et Biologie des Populations, UMR CNRS no. 5558, Université Claude Bernard, Lyon 1, 43, bd. du 11 Novembre 1918, 69622 Villeurbanne Cedex, France. perriere.goncalves@biomserv.univ-lyon1.fr

Bioinformatics (Oxford, England)
|June 15, 1999
PubMed
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JaDis is a Java application that calculates evolutionary distances for nucleic acid sequences and G+C content. This tool facilitates specific comparisons between coding and non-coding DNA sequences.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Evolution

Background:

  • The need for efficient tools to analyze nucleic acid sequence evolution.
  • Existing software limitations in comparing diverse sequence types.

Purpose of the Study:

  • To introduce JaDis, a novel Java application for sequence analysis.
  • To provide a versatile tool for computing evolutionary distances and G+C frequencies.

Main Methods:

  • Development of a Java-based application, JaDis.
  • Implementation of algorithms for calculating evolutionary distances.
  • Inclusion of functionality for G+C base frequency determination.

Main Results:

  • JaDis enables precise calculation of evolutionary distances between nucleic acid sequences.

Related Experiment Videos

  • The application computes G+C base frequencies accurately.
  • JaDis supports comparative analyses of coding, non-coding, and mixed sequence sets.

    • Conclusions:

    • JaDis offers a flexible and specific approach to analyzing nucleic acid sequence evolution.
    • The tool enhances comparative genomics by distinguishing between coding and non-coding sequence analyses.
    • JaDis is a valuable resource for researchers in molecular evolution and bioinformatics.