Preformulation stability screening of ivermectin with non-ionic emulsion excipients

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems
• Formulation Development

Background:

• Preformulation studies are critical for successful drug product development.
• Non-ionic emulsions require careful selection of compatible excipients for stability and efficacy.
• Ivermectin is an antiparasitic drug with potential applications in various formulations.

Purpose of the Study:

• To evaluate the compatibility of ivermectin with commonly used excipients for non-ionic emulsion preparation.
• To identify excipients that interact with ivermectin, potentially affecting its stability and concentration.
• To provide data for informed excipient selection in ivermectin-based formulations.

Main Methods:

• Differential Scanning Calorimetry (DSC) was employed to detect thermal interactions.
• High-Performance Liquid Chromatography (HPLC) was used to quantify ivermectin concentration after interaction studies.
• Compatibility testing was performed between ivermectin and a range of non-ionic excipients.

Main Results:

• Ivermectin exhibited significant interactions with 21 out of 46 tested excipients.
• Compatibility was observed with 25 excipients.
• HPLC analysis revealed a decrease in ivermectin concentration exceeding 20% in cases of interaction.

Conclusions:

• A substantial number of common excipients are incompatible with ivermectin for non-ionic emulsion formulation.
• Excipient-drug interactions can lead to significant degradation or loss of ivermectin.
• Careful screening using DSC and HPLC is essential to select appropriate excipients for stable ivermectin formulations.