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Updated: Oct 20, 2026
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
[Comparison of changes in oncogene of human embryo lung cells before and after chemical modification for chrysotile]
Objective:
To seek for a suitable chamical agent for surface modification of chrysotile.
Methods:
The effects of aluminum citrate, mixed rare earth and sodium selenite on c-Ha-ras oncogene and P21ras protein in the transformation of human embryo lung cells caused by chrysotile were studied.
Results:
The transcription level of c-Ha-ras oncogene and the content of P21ras in those exposed to chrysotile were significantly higher than those in the controls. The transcription level of c-Ha-ras oncogene and the content of P21ras in those exposed to chrysotile treated in advance with three kinds of chemicals mentioned above were significantly lower than those in untreated.
Conclusion:
Treatment of chrysotile with three kinds of above-mentioned chemicals in advance could reduce its carcinogenecity in human beings.
