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Related Experiment Videos

Generation of evolutionary novelty by functional shift.

M D Ganfornina1, D Sánchez

  • 1Biology Department, University of Utah, Salt Lake City 84112, USA. lazarillo@bioscience.utah.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 22, 1999
PubMed
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Evolutionary functional shifts in biological molecules are key to new traits. Distinguishing between single elements and duplicated elements adopting new functions offers a refined evolutionary framework.

Area of Science:

  • Evolutionary biology
  • Developmental biology
  • Molecular evolution

Background:

  • Biological features can change function over evolutionary time.
  • Acquisition of new functions by developmental molecules can drive significant morphological innovations.
  • Existing terms like co-option or recruitment lack nuance for diverse functional shift pathways.

Purpose of the Study:

  • To highlight the significance of a key distinction in evolutionary functional shifts: whether the element involved is single or duplicated.
  • To propose a conceptual framework for studying functional shifts with high resolution.
  • To refine the understanding of evolutionary routes involving molecular function changes.

Main Methods:

  • Review of existing evidence on functional changes, with a focus on developmental molecules.

Related Experiment Videos

  • Analysis of the interplay between co-option and gene duplication events.
  • Development of a conceptual framework for evolutionary functional shifts.

    • Main Results:

    • The historical sequence of co-option and duplication events critically influences natural selection.
    • Co-option can either drive gene duplication or stabilize redundancy post-duplication.
    • A distinction based on single vs. duplicated elements provides a more nuanced view of functional evolution.

    Conclusions:

    • The distinction between single and duplicated elements adopting new functions is crucial for understanding evolutionary pathways.
    • This refined perspective is essential for studying molecular evolution and developmental novelty.
    • The proposed framework enhances the resolution for studying functional shifts in evolutionary biology.