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Related Experiment Videos

Brain computed tomography in geriatric manic disorder.

R C Young1, D E Nambudiri, H Jain

  • 1Department of Psychiatry, Weill Medical College of Cornell University, New York, New York, USA.

Biological Psychiatry
|July 1, 1999
PubMed
Summary

Geriatric manic patients show excess brain changes, specifically greater cortical sulcal widening and ventricle-brain ratio compared to controls. These brain alterations correlate with illness onset and course, suggesting structural changes in geriatric mania.

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Area of Science:

  • Geriatric Psychiatry
  • Neuroimaging
  • Neuroscience

Background:

  • Hypothesized excess brain changes in geriatric manic patients.
  • Limited neuroimaging studies available for this population.

Purpose of the Study:

  • To investigate brain structural differences in geriatric manic patients compared to controls.
  • To explore relationships between brain changes and illness course in geriatric mania.

Main Methods:

  • Brain computed tomography (CT) scans were analyzed.
  • Geriatric patients with manic disorder (n=30) and age-matched controls (n=18) were compared.
  • Cortical sulcal widening (CSW) and lateral ventricle-brain ratio (VBR) were measured.

Main Results:

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  • Geriatric manic patients exhibited significantly greater CSW and VBR than controls.
  • CSW positively correlated with age at illness onset and first manic episode.
  • VBR showed poor correlation with CSW and no association with illness course indices.

Conclusions:

  • Findings support the hypothesis of excess brain changes in geriatric mania.
  • Further research is needed to understand brain structure-clinical feature relationships in this group.