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Published on: February 21, 2020
[Inhibitory effect of astemizol in skin tests with histamine]
R Rodríguez Medina1, S Lozada Andrade, M R Gasca Bauza
1Clínica de Asma y Alergia, Hospital General de Zona 30, Iztacalco, México, DF.
Objective:
To determine the effect of the astemizol to inhibit the cutaneous response to the histamine.
Material And Methods:
We made a clinical assay in healthy adult subjects realising skin tests with histamine for prick (1 mg/ml) and intradermal (0.01 mg/ml) daily during the taking of astemizol 10 mg during 7 days and during 7 days after suspending it, as well as the day 14, 21 and 28. It was determined the inhibition and the reappearance of the cutaneous response.
Results:
They were 12 subjects with mean age of 36 years old +/- 11.2 SD. The complete inhibition was presented starting from the fourth day and most (79%) until the seventh day. The normal reaction, recovered in more than seven days but less than fourteen in 100%.
Conclusions:
According to these results, the astemizol inhibits the skin reaction to the histamine from the first day in 50% of the subjects and its principal action is to the seventh day, while when suspend it the normal response it recovers in more than seven days.
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