Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The 5-HT1A receptor and its ligands: structure and function.

B Olivier1, W Soudijn, I van Wijngaarden

  • 1Dept. of Psychopharmacology, Faculty of Pharmacy, Utrecht University, The Netherlands.

Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progres Des Recherches Pharmaceutiques
|July 9, 1999
PubMed
Summary

Research on serotonin 5-HT1A receptors since 1983 shows many selective agonists and partial agonists are effective for anxiety and depression. Full antagonists are rare but show potential for cognitive disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of neuromuscular training strategies on injury rates in adolescent males playing sport - a systematic review and meta-analysis.

Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine·2026
Same author

Cardiorespiratory fitness response to endurance training in athletes post-COVID-19 compared to unaffected athletes.

South African journal of sports medicine·2024
Same author

Kinematic differences between left- and right-handed cricket fast bowlers during the bowling action.

South African journal of sports medicine·2024
Same author

The cycle ergometer test is not a reliable alternative to the countermovement jump in the assessment of power output.

South African journal of sports medicine·2023
Same author

The core of performance in adolescent cricket pace bowlers: Trunk muscle stability, maybe, but not strength-endurance and thickness.

South African journal of sports medicine·2023
Same author

The epidemiology of injury and illness amongst athletes at the Indian Ocean Island Games, Mauritius, 2019.

South African journal of sports medicine·2023

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • 5-HT1A receptors, discovered in 1983, are crucial targets in neuroscience.
  • Research has advanced significantly due to molecular biology tools.

Purpose of the Study:

  • To provide an overview of research progress on 5-HT1A receptors and their ligands.
  • To highlight the development and therapeutic potential of 5-HT1A receptor ligands.

Main Methods:

  • Utilizing cloned 5-HT1A receptors, mutants, and chimeras for structure-function studies.
  • Screening diverse chemical classes for high-affinity and selective 5-HT1A receptor ligands.

Main Results:

  • Numerous selective agonists and partial agonists for 5-HT1A receptors have been identified.

Related Experiment Videos

  • Agonists and partial agonists demonstrate efficacy in animal models of anxiety and depression.
  • Partial agonists are clinically effective for human anxiety and depression.

    • Conclusions:

    • 5-HT1A receptor research has yielded effective agonists and partial agonists for mood disorders.
    • Further investigation into 5-HT1A receptor antagonists may reveal applications in cognitive disorders.