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In vitro effectiveness study for hydrodynamic thrombectomy devices of the second generation
S Müller-Hülsbeck1, H Schwarzenberg, M Bathe
1Department of Radiology, University Hospital, Kiel, Germany.
Investigative Radiology
|July 10, 1999
Summary
The triple-lumen Hydrolyser (triple HL) demonstrated faster hydrodynamic thrombectomy times and lower particle embolization compared to the LF 140 Angiojet (LF 140). The triple HL is recommended for rapid mechanical thrombectomy in vitro.
Area of Science:
- Medical Devices
- Cardiovascular Interventions
- Biomedical Engineering
Background:
- Hydrodynamic thrombectomy devices are crucial for clot removal in vascular interventions.
- Comparing the efficacy and safety of different thrombectomy systems is essential for clinical practice.
Purpose of the Study:
- To evaluate the clot removal efficacy of the LF 140 Angiojet, double-lumen Hydrolyser, and triple-lumen Hydrolyser.
- To compare fluid dynamics and procedure-related particle embolization among these devices in an in vitro model.
Main Methods:
- Hydrodynamic thrombectomy was performed on porcine blood clots using LF 140, double HL, and triple HL devices in a flow model.
- Efficacy was assessed by clot removal time, remaining thrombus, fluid balance, and embolus weight.
Main Results:
- Thrombectomy time ranged from 20 seconds (triple HL) to 58 seconds (LF 140).
- The triple HL showed minimal remaining thrombus (41 mg) and low embolus weight (26 mg/0.3%).
- The LF 140 exhibited significantly higher embolus weight (675 mg/6.7%) and longer procedure times.
Conclusions:
- Device selection impacts thrombectomy time and particle embolization.
- The triple HL is the most suitable device for rapid, in vitro hydrodynamic thrombectomy.
- The LF 140's high embolization rate limits its use to small vessels.