Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Therapeutic controversies in primary hyperparathyroidism.

S J Silverberg1, J P Bilezikian, H G Bone

  • 1College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

The Journal of Clinical Endocrinology and Metabolism
|July 15, 1999
PubMed
Summary

Surgery is recommended for primary hyperparathyroidism (PHPT), even without classic symptoms. Evidence shows parathyroidectomy benefits patients with nonclassical disease and reduces long-term mortality risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome Wide Conditional Mouse Knockout Resources.

Drug discovery today. Disease models·2024
Same author

[S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

[S3 guideline sepsis-prevention, diagnosis, treatment, and aftercare : Summary of the strong recommendations].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

Efficacy and safety of denosumab vs. bisphosphonates in postmenopausal women previously treated with oral bisphosphonates.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving.

Science advances·2019
Same author

Bone mineral density gains with a second 12-month course of romosozumab therapy following placebo or denosumab.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019

Area of Science:

  • Endocrinology
  • Surgical Management
  • Metabolic Bone Disease

Background:

  • Primary hyperparathyroidism (PHPT) management traditionally focused on classical symptoms.
  • Nonclassical PHPT presentation poses challenges in treatment decisions.
  • Previous guidelines recommended surgery primarily for symptomatic or complicated cases.

Purpose of the Study:

  • To evaluate the expanding indications for parathyroidectomy in PHPT.
  • To assess the benefits of surgery in patients with nonclassical PHPT.
  • To review evidence supporting surgical intervention for improved outcomes and reduced mortality.

Main Methods:

  • Review of consensus conference recommendations and subsequent literature.
  • Analysis of evidence regarding nonclassical PHPT symptoms and their reversibility.

Related Experiment Videos

  • Evaluation of surgical outcomes and long-term mortality risks in PHPT patients.

    • Main Results:

    • Nonclassical PHPT symptoms are prevalent and reversible with surgery.
    • Subtle, "asymptomatic" harmful effects of PHPT are mitigated by parathyroidectomy.
    • Surgical intervention is associated with a reduction in increased long-term mortality risk.

    Conclusions:

    • Parathyroidectomy should be generally recommended for diagnosed PHPT, irrespective of classical symptoms.
    • The benefits of surgery extend to patients with nonclassical or "asymptomatic" PHPT.
    • Surgical management offers improved outcomes and mortality reduction in PHPT.