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Steroid-DNA conjugates: improved triplex formation with 5-amido-(7-deoxycholic acid)-dU incorporated oligonucleotides
D Bhatia1, L Yue-Ming, K N Ganesh
1Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, India.
Bioorganic & Medicinal Chemistry Letters
|July 16, 1999
Abstract:
The synthesis of oligodeoxyribonucleotides incorporating 7-deoxycholic acid conjugated at C5 of dU is described. When used as third strand, these form oligonucleotide triplexes with higher stability compared to unmodified controls at physiological pH.