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Microfluidic devices for DNA analysis
1Whitehead Institute for Biomedical Research and the Massachussetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA. ehrlich@wi.mit.edu
Trends in Biotechnology
|July 17, 1999
Abstract:
Microfabricated electrophoresis devices allow us to perform short-tandem-repeat genotyping assays in under 2 min and sequence single-stranded DNA in under 15 min. This is 10-100 times faster than standard slab-gel and capillary systems. The microdevice format is the natural extension of 100 years of gradual improvements to electrophoresis but operates in an almost-perfect way, limited only by the sieving medium.