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New classes of fluorinated L-nucleosides; synthesis and antiviral activity
1Department of Parmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens 30602, USA.
Nucleosides & Nucleotides
|August 5, 1999
Abstract:
The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'-unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F-d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.