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Intestinal absorption of cefixime in rats
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|August 7, 1999
Summary
Cefixime (Cef) absorption in rats is pH-dependent and occurs mainly in the upper intestine. Sodium edetate enhances Cef absorption, suggesting carrier-mediated and paracellular transport mechanisms.
Area of Science:
- Pharmacokinetics
- Gastrointestinal Physiology
Background:
- Understanding cefixime (Cef) intestinal absorption is crucial for optimizing its therapeutic efficacy.
- Factors influencing drug absorption impact bioavailability and treatment outcomes.
Purpose of the Study:
- To investigate the intestinal absorption characteristics of cefixime (Cef).
- To identify factors affecting cefixime absorption in the gastrointestinal tract.
Main Methods:
- An in situ rat intestine loop model was employed to assess Cef disappearance rate.
- Reversed-phase High-Performance Liquid Chromatography (HPLC) was utilized for precise Cef concentration measurements.
Main Results:
- Cefixime absorption predominantly occurred in the upper intestinal segments.
- Absorption rate showed significant pH dependency, increasing at lower pH levels.
- Uptake kinetics indicated a carrier-mediated transport system, with determined kinetic parameters (Kt, Jmax, Kd).
- Sodium edetate significantly enhanced the intestinal disappearance rate of Cef.
Conclusions:
- Cefixime absorption involves both carrier-mediated and paracellular transport pathways.
- pH and the presence of sodium edetate are key modulators of cefixime intestinal absorption.