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Combined molecular lipophilicity descriptors and their role in understanding intramolecular effects
1Institut de Chimie Thérapeutique, Section de Pharmacie, Université de Lausanne, CH-1015 Lausanne, Switzerland.
Abstract:
Traditional lipophilicity parameters (log P and log D) are well-known physico-chemical descriptors largely used in QSAR studies. Besides their numerical value, log P data contain a variety of information about inter- and intramolecular forces affecting partitioning and its related biological phenomena. The deconvolution of information from log P can be accessed only by adequate interpretative tools, such as new lipophilic-combined descriptors, of which features and some applications are presented in this review.
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