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Juvenile xanthogranuloma presenting as obstructive jaundice.

P Prasil¹, S Cayer, M Lemay

¹Centre hospitalier universitaire de Quebec, Montreal, Canada.

Journal of Pediatric Surgery

|August 12, 1999

Summary

A 9-month-old infant with obstructive jaundice was diagnosed with juvenile xanthogranuloma. This rare condition, associated with cytomegalovirus, presented as a pancreatic mass.

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Area of Science:

Pediatric Gastroenterology
Surgical Pathology
Pediatric Oncology

Background:

Obstructive jaundice in infants can stem from various causes, including rare pancreatic masses.
Cytomegalovirus (CMV) infections are common in infants and have been anecdotally linked to other rare conditions.

Observation:

A 9-month-old infant presented with obstructive jaundice and distended extrahepatic biliary tract.
Urine analysis was positive for cytomegalovirus.
A 1-cm pancreatic head mass was identified, initially concerning for malignancy.

Findings:

Intraoperative frozen section analysis could not definitively exclude malignancy.
Histopathological examination confirmed the mass as juvenile xanthogranuloma.
The final diagnosis was juvenile xanthogranuloma, with a noted association with cytomegalovirus.

Implications:

This case highlights juvenile xanthogranuloma as a rare cause of obstructive jaundice in infants.
The findings support a potential association between cytomegalovirus infection and juvenile xanthogranuloma.
Further research may elucidate the pathogenetic link between CMV and juvenile xanthogranuloma in pediatric cases.