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Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents
M Caldarelli1, J Habermann, S V Ley
1Department of Chemistry, University of Cambridge, United Kingdom.
Bioorganic & Medicinal Chemistry Letters
|August 18, 1999
Abstract:
Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step.