[Morphologic bases of clinical neurotransplantology]

Results of long term investigation performed at the Department of Morphology (Institute of the Experimental Medicine, RAMS) and data on problems of neurotransplantology and nervous tissue histogenesis in human prenatal development available in literature were summarized. Materials concerning the development of transplants of human embryonic nervous tissue (ENT) in the definitive brain of animal recipients (rats and monkeys) without immunosuppression and on the background of the effect of cyclosporine A and hydrocortisone are presented. Influence of the embryo and recipient age, as well as the volume, location (homo- and heterotopy) and method of transplantation (tissue grafts or cellular suspensions) on viability and realization of ENT histoblastic potentialities were analyzed. These data along with the findings on peculiarities of transplant structure at remote stages following the operation and authors own clinical observations were the base of practical recommendations for working out the strategy and tactics of repair and correction of functions of CNS impaired during different diseases by means of ENT transplantation.