Related Experiment Video

Updated: Oct 14, 2026

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments
12:28

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments

Published on: October 15, 2016

Potential intracellular targets for anabolic/anti-catabolic therapies

R M Palmer1, M G Thompson

  • 1Rowett Research Institute, Bucksbum, Aberdeen, UK. rmp@rri.sari.ac.uk

Current Opinion in Clinical Nutrition and Metabolic Care
|August 24, 1999
PubMed

Insights

This review explores intracellular pathways for muscle protein synthesis and breakdown. It highlights protein kinase C

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Muscle protein synthesis and proteolysis are regulated by complex intracellular signaling pathways.
  • Dysregulation of these pathways contributes to muscle wasting conditions.
  • Anabolic/anti-catabolic therapies aim to modulate these pathways for therapeutic benefit.

Purpose of the Study:

  • To review intracellular signaling pathways controlling muscle protein synthesis and proteolysis.
  • To discuss potential therapeutic targets for anabolic and anti-catabolic treatments.
  • To explore the role of protein kinase C isoforms in regulating muscle protein turnover.

Main Methods:

  • Literature review of intracellular signaling pathways.
  • Analysis of anabolic hormone potentiation and cytokine catabolic action.
  • Discussion of protein kinase C family members and their targets.

Main Results:

  • Intracellular signaling pathways offer targets for anabolic/anti-catabolic therapy.
  • Modulating anabolic hormone effects and suppressing cytokine actions are key strategies.
  • Protein kinase C isoforms play a significant role in controlling ribosomal action and protein breakdown.

Conclusions:

  • Targeting intracellular signaling pathways holds promise for muscle-related therapies.
  • Protein kinase C family members are critical regulators of muscle protein metabolism.
  • Further research into these pathways could lead to novel therapeutic interventions.

More Related Videos

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation10:35

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation

Published on: December 26, 2017

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...