Related Experiment Video

Updated: Feb 7, 2026

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
07:36

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Published on: February 28, 2021

3.5K

Interactive effects of age and respiratory virus on severe lower respiratory infection

N Prasad1, A A Trenholme2, Q S Huang1

  • 1Institute of Environmental Science and Research,Upper Hutt,Wallaceville,New Zealand.

Epidemiology and Infection
|July 27, 2018
PubMed

Insights

Influenza increases ICU admissions and hospital stays in children with severe acute lower respiratory infections (ALRI). Adenovirus (ADV) also prolongs hospital stays, with virus impact varying by age.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Severe acute lower respiratory infections (ALRI) pose a significant health burden in hospitalized children.
  • Identifying specific viral risk factors and their impact on ALRI severity is crucial for targeted interventions.

Purpose of the Study:

  • To investigate risk factors for severe ALRI in hospitalized children.
  • To determine the influence of specific viruses, such as influenza and adenovirus (ADV), on ALRI outcomes like intensive care unit (ICU) admission and length of stay (LOS).

Main Methods:

  • Retrospective analysis of hospitalized children diagnosed with ALRI.
  • Comparison of risk factors and clinical outcomes based on identified viral pathogens.

Main Results:

  • Influenza virus infection was associated with a higher risk of ICU admission and prolonged hospital stay.
  • Adenovirus (ADV) infection was linked to increased length of stay (LOS) across all age groups.
  • The impact of different viruses on ALRI severity demonstrated age-dependent variations, particularly within the first two years of life.

Conclusions:

  • Age-specific risk stratification for ALRI is essential.
  • Findings highlight the need for virus-specific interventions, including vaccines and antivirals, tailored to age groups most at risk.

Keywords:
ADV adenovirusALRI acute lower respiratory infectionICU intensive care unit admissionLOS hospital length of stayRSV respiratory syncytial viruschildrenrespiratory virussevere ALRI

More Related Videos

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.6K
Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus09:08

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

Published on: July 27, 2021

4.2K

Related Concept Videos

Anatomy of Respiratory System II: Lower Respiratory Tract01:31

Anatomy of Respiratory System II: Lower Respiratory Tract

The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
3.8K
The Respiratory System01:16

The Respiratory System

The respiratory system is comprised of the organs that enable breathing. Air enters the nostrils and mouth, followed by the pharynx (throat) and larynx (voice box), which lead to the trachea (windpipe). In the thoracic cavity, the trachea splits into two bronchi that allow air to enter the lungs. The bronchi split into progressively smaller bronchioles and terminate in small groups of tiny sacs in the lungs called alveoli, where gas exchange occurs.
89.5K
Anatomy of Respiratory System I: Upper Respiratory Tract01:29

Anatomy of Respiratory System I: Upper Respiratory Tract

The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
5.4K
Respiratory Capacities01:24

Respiratory Capacities

Respiratory capacities are crucial indicators of lung function, representing the maximum amount of air an individual's respiratory system can handle during various breathing phases.
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
1.5K
Respiratory Volumes01:15

Respiratory Volumes

Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
3.0K
Overview of Respiratory System01:23

Overview of Respiratory System

The respiratory system is a complex biological apparatus that facilitates the exchange of gases, specifically oxygen and carbon dioxide, between our bodies and the environment. This system plays a vital role in the physiological process of respiration, an essential function for sustaining life.
What is the Respiratory System?
The respiratory system consists of a series of organs responsible for taking in oxygen and expelling carbon dioxide. The primary function of the respiratory system is to...
10.1K