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Pax 6: mastering eye morphogenesis and eye evolution.

W J Gehring1, K Ikeo

  • 1Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland. gehring@ubaclu.unibas.ch

Trends in Genetics : TIG
|August 26, 1999
PubMed
Summary
This summary is machine-generated.

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Pax 6 genes are master regulators of eye development across animal phyla. These genes can trigger ectopic eye formation, suggesting a shared evolutionary origin for diverse animal eyes.

Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Genetics

Background:

  • The Pax 6 gene is a highly conserved transcription factor involved in eye development.
  • Diverse eye structures exist across metazoa, raising questions about their evolutionary origins.

Purpose of the Study:

  • To investigate the role of Pax 6 genes in eye morphogenesis across different animal phyla.
  • To explore the evolutionary mechanisms underlying the diversification of metazoan eye types.

Main Methods:

  • Comparative analysis of Pax 6 gene function in various animal species.
  • Experimental induction of ectopic eye development using Pax 6.

Main Results:

  • Pax 6 genes from diverse animal phyla successfully induced ectopic eye development.

Related Experiment Videos

  • This demonstrates the conserved function of Pax 6 as a master control gene for eye morphogenesis.

    • Conclusions:

    • Pax 6 acts as a master control gene for eye development, conserved across a wide range of animal phyla.
    • The diversity of metazoan eye types may have evolved from a single ancestral prototype via intercalary evolution.