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Related Experiment Videos

It's a knockout!

A V Anagnostopoulos1

  • 1The Jackson Laboratory, Bar Harbor, ME 04609-1500, USA. anna@jax.org

Trends in Genetics : TIG
|August 26, 1999
PubMed
Summary
This summary is machine-generated.

This update highlights new mouse knockout models in TBASE, offering concise phenotypic profiles and accessible data. Researchers can easily find and study novel mutants with unique accession numbers.

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Area of Science:

  • Genetics
  • Genomics
  • Bioinformatics

Background:

  • The Mouse Tumor Biology Database (TBASE) serves as a crucial resource for mouse genetic and phenotypic data.
  • Keeping the database updated with the latest knockout models is essential for advancing research.

Purpose of the Study:

  • To provide an updated overview of recently generated mouse knockout models.
  • To offer concise phenotypic profiles for novel mutants.
  • To ensure web accessibility of comprehensive characterization data via unique accession numbers.

Main Methods:

  • Data compilation from TBASE, focusing on new mouse knockout models.
  • Generation of concise phenotypic profiles for each mutant.
  • Assignment of unique, unchanging accession numbers (TBASE identities) for data retrieval.

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  • Categorization of knockouts by gene families, applications, or phenotypic similarities where applicable.

    • Main Results:

    • An updated selection of the latest mouse knockouts is presented.
    • Phenotypic data for novel mutants is concisely summarized.
    • Full characterization data is made directly accessible to web users through TBASE identities.
    • Knockouts are organized to facilitate discovery based on biological relationships or research interests.

    Conclusions:

    • The 'It's a Knockout!' column effectively updates researchers on new mouse knockout models.
    • TBASE provides a valuable and accessible platform for studying novel mutants.
    • Organizing knockouts enhances their utility for diverse research applications.