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Related Experiment Videos

Transgenic and knockout databases: behavioral profiles of mouse mutants.

A V Anagnostopoulos1, L E Mobraaten, J J Sharp

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 4609-1500, USA. anna@jax.org

Physiology & Behavior
|September 22, 2001
PubMed
Summary

Genetically engineered mice, including transgenics and knockouts, are vital research tools for understanding behavior genetics. Their characterization aids in developing treatments for human hereditary diseases.

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Area of Science:

  • Genetics
  • Neuroscience
  • Pharmacology

Background:

  • Genetically engineered mice (transgenic and knockout strains) are increasingly used to study the genetic basis of behavior.
  • Behavioral phenotyping of these "designer" mice offers models for evaluating treatments for human hereditary diseases.

Purpose of the Study:

  • To highlight the role of genetically engineered mice in behavioral research.
  • To describe resources available for accessing information on these mouse models and their behavioral data.

Main Methods:

  • Utilizing transgenic and gene-targeting (knockout) mouse models.
  • Conducting comprehensive behavioral phenotyping.
  • Compiling data in databases like the Induced Mutant Resource (IMR) and TBASE.

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Main Results:

  • Reported behavioral profiles encompass social, reproductive, learning, feeding, aggression, anxiety, and responses to various drugs.
  • Databases provide extensive phenotypic characterization and genetic information for numerous behavioral mutants.

Conclusions:

  • Genetically engineered mice are essential tools for deciphering behavior genetics and developing therapeutic strategies.
  • Resources like IMR and TBASE facilitate research by providing access to mouse models and detailed behavioral data.