Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Probabilistic classification learning in amnesia.

B J Knowlton1, L R Squire, M A Gluck

  • 1Department of Psychiatry, University of California School of Medicine, La Jolla 92093, USA.

Learning & Memory (Cold Spring Harbor, N.Y.)
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implicit and explicit learning of Bayesian priors differently impacts bias during perceptual decision-making.

Scientific reports·2021
Same author

Intact priming for novel perceptual representations in amnesia.

Journal of cognitive neuroscience·2013
Same author

Declarative and nondeclarative memory: multiple brain systems supporting learning and memory.

Journal of cognitive neuroscience·2013
Same author

Novel age-dependent learning deficits in a mouse model of Alzheimer's disease: implications for translational research.

Neurobiology of aging·2009
Same author

A neurocomputational model of tonic and phasic dopamine in action selection: a comparison with cognitive deficits in Parkinson's disease.

Behavioural brain research·2009
Same author

New semantic learning in patients with large medial temporal lobe lesions.

Hippocampus·2008
Same journal

Transition and renewal at <i>Learning & Memory</i>.

Learning & memory (Cold Spring Harbor, N.Y.)·2026
Same journal

Experimentally induced encoding variability influences mnemonic discrimination: evidence from human behavioral data and global matching models.

Learning & memory (Cold Spring Harbor, N.Y.)·2026
Same journal

Temporal proximity to sleep determines emotional memory interference.

Learning & memory (Cold Spring Harbor, N.Y.)·2026
Same journal

Item recognition is associated with gut microbiota composition in healthy humans.

Learning & memory (Cold Spring Harbor, N.Y.)·2026
Same journal

Memory-based similar lure rejections promote subsequent memory for relative recency.

Learning & memory (Cold Spring Harbor, N.Y.)·2026
Same journal

Chronic stress enhances threat responding and impacts fear extinction.

Learning & memory (Cold Spring Harbor, N.Y.)·2026
See all related articles

Amnesic patients and healthy controls learned probabilistic classification tasks similarly, indicating intact procedural learning. However, extended training revealed declarative memory

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Memory Research

Background:

  • Probabilistic classification learning is a complex cognitive task.
  • Amnesia can impact various memory systems, including declarative memory.
  • Understanding memory's role in learning is crucial for cognitive science.

Purpose of the Study:

  • To investigate amnesic patients' ability to learn probabilistic classifications.
  • To differentiate the roles of procedural and declarative memory in this learning task.
  • To compare human probabilistic classification learning with animal habit learning models.

Main Methods:

  • Three probabilistic classification tasks were administered to amnesic patients and control subjects.
  • Subjects learned associations between cues and outcomes with probabilistic feedback.

Related Experiment Videos

  • Performance was assessed based on accuracy over trials and savings after a delay.

    • Main Results:

    • Amnesic patients and controls showed similar initial learning rates (50% to 65% accuracy).
    • Declarative memory contributed to performance with extended training (beyond 50 trials), where controls surpassed amnesics.
    • Performance was independent of short-term memory, as evidenced by savings after a delay.

    Conclusions:

    • Amnesic patients exhibit preserved procedural learning in probabilistic classification tasks.
    • Declarative memory plays a role in probabilistic classification learning, especially with prolonged training.
    • This task serves as a human analog for hippocampal-lesion-resistant habit learning in animals.