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Related Experiment Videos

Nefazodone-induced clitoral priapism.

C C Brodie-Meijer1, W L Diemont, P J Buijs

  • 1Netherlands Pharmacovigilance Foundation Lareb, Hertogenbosch. amsterdam@lareb.nl

International Clinical Psychopharmacology
|September 1, 1999
PubMed
Summary

This case report details prolonged, painful clitoral priapism in a patient shortly after taking nefazodone hydrochloride. It highlights a potential rare side effect of this antidepressant medication.

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Area of Science:

  • Pharmacology
  • Urology
  • Women's Health

Background:

  • Priapism is a prolonged erection, often associated with medications having alpha1-adrenergic blocking properties.
  • Nefazodone hydrochloride is an antidepressant with moderate alpha1-adrenergic blocking potential.
  • Previous reports link drug-induced clitoral priapism to other antidepressants like citalopram and fluoxetine.

Observation:

  • A patient experienced a 3-day episode of painful clitoral priapism.
  • The onset of priapism strongly correlated with the administration of nefazodone hydrochloride.
  • This represents a rare instance of clitoral priapism potentially linked to nefazodone.

Findings:

  • This is the first documented case of clitoral priapism associated with nefazodone hydrochloride in medical literature.

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  • The moderate alpha1-adrenergic blocking potential of nefazodone makes this adverse event unexpected.
  • The findings suggest a possible, albeit rare, link between nefazodone and clitoral priapism.

    • Implications:

    • Clinicians should be aware of the potential for nefazodone to cause clitoral priapism, even with moderate alpha1-adrenergic blockade.
    • Further investigation may be warranted to understand the mechanism of nefazodone-induced clitoral priapism.
    • This case expands the known spectrum of drug-induced priapism and its association with antidepressants.