Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intranasal metoclopramide.

D Ormrod1, K L Goa

  • 1Adis International Limited, Auckland, New Zealand. demail@adis.co.nz

Drugs
|September 3, 1999
PubMed
Summary
This summary is machine-generated.

Intranasal metoclopramide offers an effective alternative for managing chemotherapy-induced nausea and vomiting, and functional dyspepsia, with a favorable safety profile. This new formulation demonstrates comparable efficacy to traditional routes for various indications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Velnacrine in Alzheimer's Disease : An Initial Appraisal of its Clinical Potential.

CNS drugs·2016
Same author

Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder.

CNS drugs·2013
Same author

Adjuvanted influenza vaccine.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007
Same author

Liposomal influenza vaccine.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007
Same author

Levosalbutamol.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007
Same author

Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007
Same journal

Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.

Drugs·2026
Same journal

Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.

Drugs·2026
Same journal

Use of Sedative-Hypnotic Drugs and the Risk of Developing Alzheimer's Disease: A Systematic Review, Meta-Analysis and Meta-Regression.

Drugs·2026
Same journal

Relacorilant: First Approval.

Drugs·2026
Same journal

Developmental Progress and Future Potential for Inhaled Biologics in the Treatment of Respiratory Diseases.

Drugs·2026
Same journal

Linerixibat: First Approval.

Drugs·2026
See all related articles

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Oncology

Background:

  • Metoclopramide is an established antiemetic.
  • Intranasal metoclopramide represents a novel drug delivery formulation.

Purpose of the Study:

  • To evaluate the efficacy and pharmacokinetics of intranasal metoclopramide.
  • To compare intranasal metoclopramide with oral and intramuscular formulations.
  • To assess its utility in managing chemotherapy-induced emesis, delayed emesis, and functional dyspepsia.

Main Methods:

  • Pharmacokinetic and pharmacodynamic profiling of intranasal metoclopramide.
  • Clinical trials comparing intranasal metoclopramide with parenteral and oral routes for chemotherapy-induced nausea and vomiting (CINV).
  • Studies investigating efficacy in delayed emesis, functional dyspepsia, and postoperative nausea and vomiting (PONV).

Related Experiment Videos

Main Results:

  • Intranasal metoclopramide demonstrated similar efficacy to intramuscular and oral routes for acute and delayed CINV.
  • Significant reduction in vomiting frequency observed in patients receiving highly emetogenic chemotherapy.
  • Comparable efficacy to oral metoclopramide for functional dyspepsia.
  • Minor nasal irritation and unpleasant taste were the main side effects; serious extrapyramidal effects were not reported.

Conclusions:

  • Intranasal metoclopramide is an effective and well-tolerated alternative for managing nausea and vomiting, particularly in the context of chemotherapy.
  • The intranasal route provides a viable option with a similar efficacy and safety profile to conventional administration methods.
  • Further research may explore its role in PONV and other gastrointestinal disorders.