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Melatonin and jet-lag.

A Samel1

  • 1DLR-Institute of Aerospace Medicine, Linder Höhe, D-51147 Köln, Germany. alexander.samel@dlr.de

European Journal of Medical Research
|September 8, 1999
PubMed
Summary
This summary is machine-generated.

Melatonin use for jet-lag has mixed results, with inconsistent field study data and potential side effects. More clinical research is needed before general recommendations for melatonin can be made.

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Area of Science:

  • Chronobiology
  • Sleep Medicine
  • Pharmacology

Background:

  • Transmeridian flight causes circadian rhythm desynchronization, leading to jet-lag.
  • Melatonin is commonly used by travelers to mitigate jet-lag symptoms.
  • The efficacy of melatonin for jet-lag alleviation is debated, with inconsistent findings.

Purpose of the Study:

  • To review the current evidence on melatonin's effectiveness for jet-lag.
  • To assess the impact of melatonin on sleep and circadian rhythm resynchronization.
  • To identify gaps in knowledge regarding optimal melatonin dosage and timing.

Main Methods:

  • Analysis of field studies, including questionnaire-based and physiological monitoring.
  • Review of laboratory experiments investigating melatonin's effects on the circadian system.

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  • Evaluation of existing data on melatonin dosage, timing, and adverse effects.

    • Main Results:

    • Field studies show mixed results, with some suggesting benefits and others lacking conclusive evidence.
    • Laboratory studies confirm melatonin's ability to influence circadian rhythms.
    • Information on optimal dosage, timing, and performance effects is limited and inconsistent.
    • Adverse effects like sleepiness and impaired performance are known, especially with inappropriate timing.

    Conclusions:

    • Current evidence does not support general recommendations for melatonin use in aircrew.
    • Further rigorous clinical studies are required to establish efficacy and safety.
    • Flight physicians should be aware of melatonin's potential adverse effects.