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Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine
1Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Japan. shibata@life.shimane-u.ac.jp
Bioscience, Biotechnology, and Biochemistry
|September 9, 1999
Abstract:
Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, from I-->form II-->form III, induced by 3 mM monochloramine with a half inhibition of 67.4 microM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.