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Surface characterization and platelet adhesion studies on polyurethane surface immobilized with C60.
1Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan. jclin@mail.ncku.edu.tw
Biomaterials
|September 11, 1999
Summary
Fullerenes (C60) grafted onto polyurethane surfaces enhance platelet activation. This fullerene-grafted PU may offer new biomaterials for cell adhesion and growth applications.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Surface Chemistry
Background:
- Fullerenes (C60) possess unique molecular properties driving research in diverse applications.
- Polyurethane (PU) is a versatile polymer with potential for biomedical uses.
- Surface modification of polymers is crucial for tailoring their biological interactions.
Purpose of the Study:
- To graft C60 molecules onto polyurethane surfaces.
- To investigate the surface chemistry changes after C60 grafting.
- To evaluate the effect of C60-grafted PU on platelet adhesion.
Main Methods:
- Oxygen plasma activation of PU surface.
- Grafting of C60 using amine-terminated silane coupling agents (4-aminobutyldimethylmethoxysilane).
- Electron Spectroscopy for Chemical Analysis (ESCA) for surface characterization.
- In vitro platelet adhesion assay.
Main Results:
- C60 molecules successfully grafted onto the PU surface via nucleophilic addition.
- Increased amine functional groups observed on the PU surface with specific coupling agents.
- C60-grafted PU exhibited significantly higher platelet activation compared to untreated PU.
- Synergistic effects of C60 and residual amine groups likely contribute to platelet activation.
Conclusions:
- Successful surface functionalization of PU with C60 was achieved.
- C60-grafted PU demonstrates enhanced pro-thrombotic properties due to C60 and amine groups.
- These modified surfaces show potential for applications in cell adhesion and growth substrates.