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Related Experiment Videos

Dystroglycan inside and out.

M D Henry1, K P Campbell

  • 1Howard Hughes Medical Institute Department of Physiology and Biophysics Department of Neurology University of Iowa College of Medicine 400 Eckstein Medical Research Building, Iowa City, IA 52242, USA. michael-henry@uiowa.edu.

Current Opinion in Cell Biology
|October 6, 1999
PubMed
Summary
This summary is machine-generated.

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Dystroglycan, a protein linking the extracellular matrix and cytoskeleton, interacts with more ligands and organizes matrix molecules. It also serves as an entry point for pathogens, revealing its crucial roles in development and disease.

Area of Science:

  • Cell biology
  • Molecular biology
  • Biochemistry

Background:

  • Dystroglycan serves as a crucial physical link between the extracellular matrix and the intracellular cytoskeleton.
  • Its role in cell adhesion and tissue integrity is well-established.
  • Recent research has expanded the understanding of its molecular interactions and biological significance.

Purpose of the Study:

  • To summarize recent key findings regarding dystroglycan's interactions and functions.
  • To highlight the expanded repertoire of extracellular ligands bound by dystroglycan.
  • To elucidate the role of dystroglycan in matrix organization and pathogen entry.

Main Methods:

  • Literature review of recent studies on dystroglycan.
  • Analysis of protein-ligand interactions.

Related Experiment Videos

  • Investigation of dystroglycan's role in matrix organization.
  • Examination of pathogen interactions with dystroglycan.

    • Main Results:

    • Dystroglycan interacts with a broader range of extracellular matrix ligands than previously known.
    • Dystroglycan is essential for organizing extracellular matrix components on cell surfaces and in basement membranes.
    • At least two human pathogens exploit dystroglycan for host cell entry.

    Conclusions:

    • Recent advances reveal expanded functions of dystroglycan beyond its established role.
    • Dystroglycan's involvement in matrix organization and pathogen interaction highlights its significance in development and disease.
    • Further research into dystroglycan promises deeper insights into cellular processes and pathologies.