Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Squamometry in seborrheic dermatitis.

C Piérard-Franchimont1, V Willemaers, A L Fraiture

  • 1Department of Dermatopathology, University Medical Center Sart Tilman, Liège, Belgium.

International Journal of Dermatology
|October 12, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Mammary Paget's disease].

Revue medicale de Liege·2011
Same author

[Behind the scenes of breast cancer].

Revue medicale de Liege·2011
Same author

Specular light reflectance of flakes in seborrhoeic dermatitis of the scalp: a pilot study.

Clinical and experimental dermatology·2011
Same author

[Image of the month. Necrobiosis lipoidica].

Revue medicale de Liege·2011
Same author

[Unraveling the ichthyosis types].

Revue medicale de Liege·2011
Same author

[Image of the month. Occupational diseases of hairdressers: interdigital pilonidal sinus].

Revue medicale de Liege·2011
Same journal

SENTINOLD and the Challenge of Meaningful Risk Prediction in Melanoma.

International journal of dermatology·2026
Same journal

The "Stamp-n-Tack" Technique: An Ink-Guided Precision Method for Anchoring Tissue After Releasing Facial Retaining Ligaments in Large Facial Flap Reconstruction.

International journal of dermatology·2026
Same journal

Counterfactual Dermatology With Generative Models.

International journal of dermatology·2026
Same journal

Correlation of Clinical and Histopathological Features With Anti-Desmoglein Antibody Profile in Pemphigus Patients.

International journal of dermatology·2026
Same journal

Paracetamol-Induced Generalized Bullous Fixed Drug Eruption With Positive Anti-BP230 Antibody and Confirmed With Oral Provocation Test in a Child: A Case Report From the Philippines.

International journal of dermatology·2026
Same journal

Clinicopathological Challenge: A Painful Violaceous Reticulated Patch.

International journal of dermatology·2026
See all related articles

Hydrocortisone butyrate in an oil-in-water emulsion showed a faster onset of efficacy for seborrheic dermatitis compared to betamethasone dipropionate lotion. The vehicle likely enhanced the anti-inflammatory action.

Area of Science:

  • Dermatology
  • Pharmacology
  • Biophysics

Background:

  • Seborrheic dermatitis is a common skin condition responsive to topical corticosteroids.
  • Topical corticosteroid efficacy depends on the drug and its vehicle, which affects penetration and stratum corneum function.

Purpose of the Study:

  • To compare the early treatment response of seborrheic dermatitis to two topical corticosteroids.
  • To objectively quantify stratum corneum alterations using squamometry.

Main Methods:

  • Squamometry was employed to assess therapeutic activity.
  • Two formulations were compared: 0.1% hydrocortisone butyrate in an oil-in-water emulsion (Locoid Crelo) and 0.05% betamethasone 17-21 dipropionate lotion (Diprosone lotion).

Main Results:

Related Experiment Videos

  • Hydrocortisone butyrate formulation demonstrated a quicker onset of action.
  • Greater lesion improvement was observed after one week of twice-daily treatment with hydrocortisone butyrate.
  • Both treatments led to clearance or marked improvement by the end of the two-week trial.

Conclusions:

  • Clinical efficacy ranking did not correlate with the intrinsic anti-inflammatory potency of the steroids.
  • The formulation vehicle is suggested to contribute significantly to overall in vivo efficacy.
  • The emollient effect of the oil-in-water emulsion may synergistically enhance the anti-inflammatory action of hydrocortisone butyrate.