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[Hypocholesterolemias: causes and diagnosis].
1UF lipides-dyslipidémies, Laboratoire de biologie, Hôpital neurologique, 59, boulevard Pinel, 69003 Lyon.
Annales De Biologie Clinique
|October 13, 1999
Summary
Low serum cholesterol (hypocholesterolemia) in children and adults carries non-cardiovascular risks like cancer and depression. Diagnosis involves lipid tests, with genetic testing for familial cases.
Area of Science:
- Endocrinology
- Clinical Biochemistry
Context:
- Hypocholesterolemia, or low serum cholesterol, affects both adults and children.
- Non-cardiovascular risks associated with low cholesterol include cancer and depressive illness.
- Accurate assessment is crucial for understanding the implications of hypocholesterolemia.
Purpose:
- To present the various forms of hypocholesterolemia in adults and children.
- To discuss the non-cardiovascular risks linked to low serum cholesterol.
- To outline diagnostic approaches for hypocholesterolemia.
Summary:
- Hypocholesterolemia diagnosis is typically achieved through standard lipid profiles (total, HDL- and LDL-cholesterol, apolipoproteins B and A1).
- Familial hypocholesterolemias may require parental lipid assays for comprehensive assessment.
- Secondary hypocholesterolemias are identifiable in common conditions like liver disease or hyperthyroidism, but can be challenging in cases of fever, trauma, or inflammation.
Impact:
- Highlights the importance of recognizing non-cardiovascular risks of hypocholesterolemia.
- Guides appropriate diagnostic strategies, differentiating between common and rare familial conditions.
- Emphasizes the judicious use of extensive laboratory investigations, reserving them for severe familial hypocholesterolemias to advance treatment and knowledge.