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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Hepatitis E virus infection in travelers
E Schwartz1, N P Jenks, P Van Damme
1Sheba Medical Center, Tel-Hashomer, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Summary
Hepatitis E virus (HEV) causes hepatitis in travelers to endemic areas, primarily young adults. While rare, severe cases can be fatal, especially in pregnant women or those with liver disease.
Area of Science:
- Hepatology
- Infectious Diseases
- Travel Medicine
Background:
- Hepatitis E virus (HEV) is a significant cause of hepatitis in endemic regions.
- Infection predominantly affects young adults and international travelers.
Purpose of the Study:
- To investigate the characteristics and outcomes of acute HEV infection in travelers.
- To review existing literature on HEV infections acquired in endemic areas.
Main Methods:
- Case report of 5 travelers with acute HEV infection.
- Literature search and review of 143 HEV infection cases contracted in endemic areas.
Main Results:
- Fulminant hepatitis occurred in 2.7% of reviewed cases, with 2 fatalities.
- The Indian subcontinent was the most common travel destination for infected travelers.
- HEV infection risk for travelers is lower than for Hepatitis A virus.
Conclusions:
- HEV infection is a concern for travelers to endemic regions, particularly the Indian subcontinent.
- Pregnant women and individuals with pre-existing liver conditions are at higher risk for severe HEV infection.
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