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Second primary tumors after prostate carcinoma.

F Levi1, L Randimbison, V C Te

  • 1Registre Vaudois des Tumeurs, Institut Universitaire de Médecine Sociale et Préventive, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Cancer
|October 20, 1999
PubMed
Summary
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Men diagnosed with prostate cancer showed a reduced risk of developing other cancers. This study found no increased risk for urologic or tobacco-related neoplasms, suggesting no link between smoking and prostate cancer.

Area of Science:

  • Oncology
  • Cancer Epidemiology
  • Prostate Cancer Research

Background:

  • Previous studies indicate a reduced risk of all neoplasms post-prostate carcinoma diagnosis.
  • An elevated incidence of urologic carcinoma has been suggested following prostate cancer diagnosis.

Purpose of the Study:

  • To estimate the incidence rate of second primary tumors after a prostate carcinoma diagnosis.
  • To investigate the association between prostate cancer and subsequent urologic or tobacco-related neoplasms.

Main Methods:

  • Utilized data from Swiss Cancer Registries (Vaud and Neuchâtel) covering approximately 760,000 inhabitants.
  • Analyzed 4503 prostate carcinoma cases diagnosed between 1974 and 1994, with follow-up until the end of 1996 (17,065 person-years).

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Main Results:

  • Observed 380 second primary neoplasms versus 534.1 expected (Standardized Incidence Ratio [SIR] = 0.7; 95% CI, 0.6-0.8).
  • Significantly lower SIRs for lung carcinoma (SIR = 0.7) and major tobacco-related neoplasms (mouth/pharynx SIR = 0.5, esophagus SIR = 0.4, pancreas SIR = 0.5, larynx SIR = 0.8).
  • No excess risk for subsequent urologic carcinoma (SIR = 1.0) or colorectal carcinoma (SIR = 0.9).

Conclusions:

  • Overall incidence of all neoplasms was significantly reduced in men with prostate carcinoma.
  • Potential explanations include population selection, under-registration of second tumors, and reduced surveillance in elderly patients.
  • Findings do not support an association between cigarette smoking and prostate carcinoma.