Related Experiment Video
Updated: Aug 13, 2026
Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
Mobility challenges and solutions for fibrodysplasia ossificans progressiva
C Levy1, T F Berner, P S Sandhu
1Department of Physical Medicine and Rehabilitation, The Ohio State University Medical Center, Columbus, USA.
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder causing progressive bone formation in soft tissues. This case study highlights adaptive equipment and physiatric interventions enabling an individual with advanced FOP to maintain employment and independence.
Area of Science:
- Medical Genetics
- Rehabilitation Medicine
- Skeletal Dysplasias
Background:
- Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification of soft tissues.
- Ectopic bone formation typically begins in early childhood, primarily affecting axial musculature and progressing to ligaments, tendons, and joint capsules.
Observation:
- This report details a 30-year-old woman with advanced FOP, presenting with a fused spine, fixed pelvis, and severe joint contractures in all limbs.
- The patient experienced profound mobility limitations, rendering her unable to stand or sit independently.
Findings:
- A modified power wheelchair and custom footwear were successfully implemented, enabling the patient to continue her employment as a preschool teacher.
- Creative physiatric interventions were crucial in adapting to the patient's functional limitations.
Implications:
- This case underscores the importance of innovative assistive technologies and tailored rehabilitation strategies for individuals with severe FOP.
- Such interventions can significantly enhance quality of life, promote independence, and facilitate continued participation in meaningful activities for those with rare genetic disorders.
More Related Videos
09:26An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
Published on: October 23, 2017
07:43In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
Published on: July 2, 2021
Related Concept Videos
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...