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Donor variation in the growth properties and osteogenic potential of human marrow stromal cells
D G Phinney1, G Kopen, W Righter
1Center for Gene Therapy, MCP Hahnemann University, Philadelphia, Pennsylvania 19102, USA. phinney@auhs.edu
Journal of Cellular Biochemistry
|October 28, 1999
Abstract:
Human marrow stromal cells (MSCs) were isolated from posterior illiac crest marrow aspirates obtained from 17 healthy donors, ages 19-45 years, with no apparent physical disability. First passage hMSCs exhibited growth rates in vitro that varied up to 12-fold between donors. No correlation between growth rate and the age or gender of the donor was evident (P