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[Aminopeptidases in human leukemia cells]
T A Gureeva1, N V Golubeva, O N Lubkova
1Institute of Biomedical Chemistry, Moscow.
Voprosy Meditsinskoi Khimii
|November 5, 1999
Abstract:
Aminopeptidase activity in lymphoid cells of patients with various lymphoproliferative diseases was studied. The enzyme activity was detected in lysates of all leukemic B- and T-cells. The lymphoid cells contained aminopeptidases of at least two classes: metallo- and SH-dependent enzymes. The SH-dependent aminopeptidase with pH optimum 8.5-9.0 was revealed in lymphoid cells for the first time, and it seems to belong to a poorly studied aminopeptidase family.