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Acquired amegakaryocytic thrombocytopenic purpura (AATP): a hospital based study
1Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi.
Objective:
To determine the frequency of Acquired Amegakaryocytic Thrombocytopenic Purpura (AATT), possible aetiology, course and prognosis.
Design:
Retrospectively diagnosed patients, treated and followed prospectively.
Setting:
Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi.
Subjects:
One hundred twenty patients with thrombocytopenic purpura.
Main Outcome Measures:
Response to treatment and course of disease.
Results:
Out of 22 patients 2 died of cerebral haemorrhage, one transformed to Myelodysplastic Syndrome (MDS), one transformed to Acute Myeloid Levkaenia (AML). None is transfusion independent.
Conclusion:
AATT is not an infrequent disorder. It shows poor response to all available therapeutic modalities and has a potential for transformation into Myelodysplasia and acute myeloid leukaemia.