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Role of keratinocyte injury in adherence of Streptococcus pyogenes
G L Darmstadt1, L Mentele, P Fleckman
1Divisions of Infectious Diseases, Department of Pediatrics, Children's Hospital & Regional Medical Center, Seattle, Washington 98105, USA.
Infection and Immunity
|November 24, 1999
Abstract:
Keratinocytes injured acutely by UVB light or lipopolysaccharide were used to test the hypothesis that keratinocyte injury promotes bacterial adherence and the development of group A streptococcal skin infections. Injury did not affect adherence to undifferentiated and differentiated keratinocytes, but keratinocyte differentiation promoted adherence four- to fivefold.