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Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of
S Kirkiacharian1, P G Koutsourakis, D Philibert
1Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, Chatenay-Malabry, France. serge.kirkiacharian@cep.u-psud.fr
Farmaco (Societa Chimica Italiana : 1989)
|November 27, 1999
Abstract:
The study of the relative binding affinity of a set of 2,3-disubstituted indenes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproliferative effect on human MCF-7 cells also shows a weak activity for three derivatives.