[The modulators of the estrogenic activity]

¹Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud 5, rue Jean-Baptiste Clément F 92296 Chatenay-Malabary Cedex.

|January 10, 2001

Abstract:

The biological, pharmacological and therapeutic properties of estrogens/antiestrogens are related to their chemical structure. Tamoxifen, used for the treatment of hormone-dependent breast cancer, and other analogue derivatives of triarylethylene or presenting a cyclic or heterocyclic structure, mimic some of the activities of estrogens. They have major therapeutic potential as selective estrogen receptor modulators in the prevention of breast cancer and various post-menopausal conditions.

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

[Synthesis and binding affinity to human steroid hormone receptors of 3-phenoxy-4-hydroxycoumarins and 3-phenoxy-4-phenylcoumarins].

Annales pharmaceutiques francaises·2017

[Synthesis and binding affinity of 3-aryl-7-hydroxycoumarins to human alpha and beta estrogen receptors].

Annales pharmaceutiques francaises·2003

[New total synthesis of derrusnine].

Annales pharmaceutiques francaises·2002

Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes.

Farmaco (Societa chimica italiana : 1989)·1999

[Binding affinity to steroid hormone receptors and antiproliferative action on MCF-7 cells of coumarin derivatives and isoflavonoids].

Annales pharmaceutiques francaises·1999

[Free radical scavenging activity of 4-hydroxycoumarin derivatives].

Annales pharmaceutiques francaises·1999

See all related articles

Related Experiment Videos

[The modulators of the estrogenic activity]

Related Concept Videos

[Synthesis and binding affinity to human steroid hormone receptors of 3-phenoxy-4-hydroxycoumarins and 3-phenoxy-4-phenylcoumarins].

[Synthesis and binding affinity of 3-aryl-7-hydroxycoumarins to human alpha and beta estrogen receptors].

[New total synthesis of derrusnine].

Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes.

[Binding affinity to steroid hormone receptors and antiproliferative action on MCF-7 cells of coumarin derivatives and isoflavonoids].

[Free radical scavenging activity of 4-hydroxycoumarin derivatives].

EsChemGame: An escape room approach in practical laboratory sessions for pharmacy students.

Proposal for a new definition of health: an anthropological reappraisal based on a cross-sectional survey.

Health practitioners at sea: Evolution of a practice and a profession on ships flying the French flag (18th-19th century).

[Difficulties and needs of family caregivers of elderly patients in the care pathway and medication management].

[Theoretical and practical training in managing requests for injectable anticancer drugs and galenic preparations on pharmaceutical duty].

[Early feasibility studies in Europe: Challenges, perspectives, and expected impacts on the clinical evaluation of medical devices].

Green and Efficient Extraction of Puerarin-Enriched Extracts From Pueraria lobata via Subcritical Ethanol-Water for Multi-Target Antidiabetic Effects.

Inter- and intramolecular photoactivation of artemisinin and derivatives by xanthone-based triplet and singlet sensitizers.

Design and evaluation of an amphiphilic biaryl ether library using a novel cell-based β-arrestin recruitment assay for the octopamine receptors of Balanus improvisus.

One-Step Synthesis of Dihydropyrroloquinazolinone Alkaloid Natural Products: S‑(-)- and R‑(+)-Vasicinone and Their Novel Analogues.

Phthalazine as a medically versatile polyheterocyclic core with underexplored anticancer potential.

Recent advances in the therapeutic potential of quinoline-piperazine hybrids.

Related Experiment Videos

[The modulators of the estrogenic activity]

Abstract:

Related Concept Videos

Related Articles