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The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000
1Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland. amos.bairoch@medecine.unige.ch
Nucleic Acids Research
|December 11, 1999
Summary
SWISS-PROT is a curated protein sequence database offering detailed annotations and minimal redundancy. Recent updates enhance its content, integration, and include TrEMBL, a supplement for computer-annotated protein sequences.
Area of Science:
- Bioinformatics
- Molecular Biology
- Proteomics
Background:
- SWISS-PROT is a vital resource for protein sequence and functional data.
- High-quality annotation and integration are crucial for biological research.
Purpose of the Study:
- To describe the SWISS-PROT database, its features, and recent developments.
- To introduce TrEMBL as a computer-annotated supplement.
- To highlight the Human Proteomics Initiative (HPI).
Main Methods:
- Curated protein sequence data compilation.
- Development of enhanced annotation standards.
- Integration with other biological databases.
- Computer-based annotation of coding sequences (CDSs).
Main Results:
- SWISS-PROT provides comprehensive protein annotations, including function, domains, and modifications.
- TrEMBL expands coverage with computer-annotated sequences from EMBL.
- The Human Proteomics Initiative aims for complete human sequence annotation.
Conclusions:
- SWISS-PROT and TrEMBL are essential, continuously improving resources for protein data.
- The Human Proteomics Initiative advances human proteome research.
- Database integration and annotation quality are key for advancing biological discovery.