Mouse tumor biology database (MTB): enhancements and current status

Area of Science:

• Comparative oncology
• Genetics and genomics
• Translational research

Background:

• The laboratory mouse is a critical model for understanding human cancer genetics and disease progression.
• Genetically defined mouse models, including transgenics and targeted mutations, are essential tools in cancer research.
• A centralized repository for curated data on mouse tumor biology is needed to support the research community.

Purpose of the Study:

• To establish a comprehensive, web-based resource for mouse tumor biology data.
• To provide researchers with detailed information on tumor frequency, latency, genetics, and pathology in genetically defined mice.
• To facilitate the use of mouse models in understanding human disease processes.

Main Methods:

• Data compilation from the primary scientific literature.
• Inclusion of direct data submissions from the research community.
• Web-based accessibility through the Mouse Genome Informatics (MGI) website.

Main Results:

• The Mouse Tumor Biology Database (MTB) provides integrated access to diverse data types.
• Information covers tumor characteristics across various genetically defined mouse strains.
• Data includes tumor frequency, latency, genetic alterations, and pathological features.

Conclusions:

• MTB serves as a valuable information resource for cancer genetics researchers.
• The database supports the use of mouse models for investigating human cancer.
• MTB enhances research efficiency by consolidating critical biological data.