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Quantitative trait locus detection using combined linkage/disequilibrium analysis
L Almasy1, J T Williams, T D Dyer
1Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA.
Genetic Epidemiology
|December 22, 1999
Abstract:
We describe an extension of the variance component linkage method that augments identity-by-descent information from relatives with identity-by-state information from unrelated individuals, exploiting disequilibrium to facilitate fine mapping of quantitative trait loci. An advantage of the combined linkage/disequilibrium test is that it detects association only in the presence of linkage and is not biased by population stratification.