Related Experiment Videos
Orelox (cefodoxime) in typhoid fever
A Dhanjee1, M A Sheikh, M Yaqub
1Dhanjee Clinic, Clifton, Karachi.
Insights
Cefodoxime (Orelox) demonstrated 86% efficacy in treating pediatric typhoid fever, showing significant clinical improvement. This study suggests it is a safe and effective option for children with this common infection.
Area of Science:
- Pediatric infectious diseases
- Pharmacology and therapeutics
Background:
- Typhoid fever remains a significant public health concern in children, particularly in endemic regions.
- Effective antibiotic treatment is crucial for managing typhoid fever and preventing complications.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of Cefodoxime (Orelox) for treating typhoid fever in pediatric patients.
Main Methods:
- An open-label, non-comparative, multicenter study was conducted across general practice settings in Pakistan.
- The study included 77 children aged 1-15 years with a confirmed diagnosis of typhoid fever based on a positive Widal test.
Main Results:
- Overall, 86% of the pediatric patients achieved a clinical cure or improvement.
- Specifically, 79% were cured, and 7% showed improvement in signs and symptoms, while 14% experienced treatment failure.
Conclusions:
- Cefodoxime (Orelox) exhibited an 86% efficacy rate in producing clinical responses in children with typhoid fever.
- The findings suggest that Cefodoxime is a safe and effective therapeutic option for pediatric typhoid fever management.
Objective:
To study the efficacy of Orelox (Cefodoxime) in Typhoid fever in children.
Settings:
Open, non-comparative, multicentre study carried out in GP settings in various cities of Pakistan.
Patients:
Children aged 1-15 years were included in the study. Positive Widal test was the only diagnostic inclusion criteria.
Results:
Four centers participated in the study. Of the total 77 patients (51 males and 26 females), 61 (79%) cured, 5 (7%) improved (less severe signs and symptoms) and 11 (14%) failures.
Conclusion:
Treatment of typhoid fever in this study showed 86% efficacy in producing clinical responses suggesting that this drug can be effectively and safely used in the treatment of typhoid fever in children.