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Radiation-associated choroidal neovasculopathy.

R F Spaide1, A Leys, B Herrmann-Delemazure

  • 1NY LuEsther T. Mertz Retinal Research Laboratory, Manhattan Eye, Ear & Throat Hospital, New York, New York 10021, USA. rspaide@earthlink.net

Ophthalmology
|December 22, 1999
PubMed
Summary
This summary is machine-generated.

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Radiation therapy for age-related macular degeneration can cause a new choroidal vascular abnormality, termed radiation-associated choroidal neovasculopathy. This condition is associated with significant vision loss and a poor prognosis.

Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Vascular Biology

Background:

  • Age-related macular degeneration (AMD) is a leading cause of vision loss.
  • Choroidal neovascularization (CNV) is a key feature of wet AMD.
  • Radiation therapy is an established treatment for subfoveal CNV.

Purpose of the Study:

  • To characterize a newly discovered choroidal vascular abnormality.
  • To investigate the incidence of this abnormality in patients treated with radiation for CNV.
  • To describe the clinical features and prognosis of this radiation-induced vascular change.

Main Methods:

  • Two-center cross-sectional study.
  • Retrospective examination of 193 patients treated with external beam photons (10-20 Gy).

Related Experiment Videos

  • Patients were evaluated for a specific CNV abnormality using fluorescein angiography and indocyanine green angiography.

    • Main Results:

    • An unusual vascular growth pattern, termed radiation-associated choroidal neovasculopathy, was identified in 19 patients (9.8%).
    • This abnormality presented as round or oval vascular blebs along the outer border of neovascular lesions.
    • These blebs showed significant leakage on fluorescein angiography and were best imaged with indocyanine green angiography, correlating with marked visual acuity loss.

    Conclusions:

    • Radiation therapy for CNV can lead to a distinct choroidal vascular abnormality.
    • Radiation-associated choroidal neovasculopathy is a recognizable disorder with a poor prognosis.
    • This finding highlights a potential complication of radiation treatment for AMD.